A VDR is a valuable tool https://dataroomapps.net/data-management-made-simple-how-virtual-data-rooms-can-simplify-your-complex-business-processes when external parties require access to confidential information. For instance, when legal counsel accountants, auditors, or legal counsel require access to documents belonging to the company, the leadership team must find an avenue to allow this without putting at risk the possibility of data being stolen or compromised. A VDR can aid in these instances by facilitating sharing of documents with other entities that have stringent security measures already in place.
The genomic functions of VDR are dependent upon its binding to 1,25(OH2)2D3 which stimulates dimerization, which allows binding to Vitamin D Response Elements (VDRE) within vitamin D target genes. In the absence of RXR, VDR cannot bind to most VDRE in the genome, and consequently, it has very little direct genomic effects. Future studies are needed to determine the locations that ligand binding can facilitate binding of DNA regulatory regions by RXR or VDRE and the molecular mechanisms that control gene expression.
In naive T cells, the antigen-specific stimulation of T cell receptors (TCR) results in intracellular signaling processes that lead to the upregulation of VDR. This upregulation is required for cells in naive states to respond to steroid hormones and peptide hormones and initiate adaptive immune responses. The regulatory DNA elements cis-acting required to trigger this VDR activated have not been identified yet, but they are likely to involve direct interaction with p38 kinase.